The Scottish DJ notched his fifth number one as a lead artist and seventh in total with Blame featuring John Newman at the summit this weekend.
Harris previously topped the charts with I’m Not Alone (2009), Sweet Nothing (2012), Under Control (2013) and Summer (2014), while he also featured on Dizzee Rascal’s Dance Wiv Me (2008) and Rihanna’s We Found Love (2011).
Just over 13% of Blame’s combined chart sales figure comes from audio streaming from services such as Spotify, Deezer and O2 tracks, the Official Charts Company said.
Last week’s number one Lilly Wood & Robin Schulz’s Prayer In C slipped to number two, but the single was the most streamed track of the week, with nearly 1.4 million audio streams.
Magic!’s Rude (Number 9) and Sam Smith’s Stay With Me (15) have also hit the million mark this week with 1.1 million and 1 million streams respectively.
Meanwhile, Smith’s I’m Not The Only One is at number three, followed by Taylor Swift’s Shake It Off, which spends a fourth consecutive week in the Top 10 at four and Iggy Azalea’s Black Widow featuring Rita Ora making up the top five.
There were three other new entries in today’s Official Singles Chart Top 40 – Walking With Elephants (Number 6) by house producer Ten Walls, Chris Brown with New Flame featuring Usher and Rick Ross (Number 10), and US rockers Fall Out Boy at 22 with Centuries.
Meanwhile Robert Plant scored this week’s highest new entry in the albums chart.
The Led Zeppelin frontman’s 10th solo collection Lullaby And The Ceaseless Roar entered the chart at number two, missing out to Smith’s In The Lonely Hour, which has now been at the summit for four weeks in a row.
Plant, 66, now has 34 albums chart top 40s to his name, including 20 with rock legends Led Zeppelin.