Some hospital workers have tested positive for coronavirus forcing authorities to shut the facility.
Zweli Mkhize, the South African health minister, said the outbreak occurred at St Augustine hospital in Durban.
Sixty-six people tested positive to the virus, the minister announced on Tuesday as the country’s cases rose to 1,749. Of those infected, 48 are hospital workers.
South Africa has reported 13 deaths so far, including four at the same hospital.
The country is currently observing a 21-day lockdown to curb the spread of coronavirus.
President Cyril Ramaphosa said on Tuesday that the lockdown has thus far helped slow down the spread.
“If we had not locked down South Africa as we have, I can tell you without any shadow of doubt that the infection rate… would have been a lot, lot higher than what we have,” he said.